Fresenius-Kabi - Lactulose


Multiple benefits

Mode of action
Lactulose has three major effects: 

• It acts as an energy source for bacteria
Prebiotics are food ingredients that have beneficial health effects by selectively stimulating the growth and/or activity of colonic bacteria. It has been demonstrated that Lactulose is used as a carbohydrate resource by bifidobacteria and lactobacilli in the human colon. The main effects of this fermentation process are a drop of pH in the colon and a favourable change in composition and metabolic activity of the intestinal flora.

• It acts as an osmotically active laxative 
Lactulose is degraded in the colon by saccharolytic bacteria, like lactobacilli, into short-chain fatty acids (SCFA). Thus the intestinal content acidifies, the osmotic pressure rises, and stool volume increases. Furthermore, intestinal peristalsis is enhanced. This leads to the laxative effect of Lactulose characterised by a shorter colon transit time and accelerated bowel movement.

• It reduces blood ammonia levels
Lactulose promotes the growth of gut bacteria and increases biomass. For the synthesis of bacterial protein, ammonia and nitrogen are used. At the same time, production of ammonia is inhibited by acidifying the intestinal content. This reduces the passage of free ammonia from the intestine into the blood. Together with a shortened transit time and a decreased residence time of ammonia in the intestinal lumen, the excretion of ammonia with the stool is accelerated. The sum of these effects leads to a reduction of blood ammonia levels.